Peakdale Molecular - Medicinal Chemistry
Peakdale has built up medicinal chemistry and computational chemistry expertise across therapeutic areas and spanning the drug discovery process from hit generation to Phase I clinical studies.
Peakdale has a proven track record of success in producing robust candidates suitable for
Proof-of-concept testing in vivo. To achieve this, the company utilises its highly experienced
and committed teams to deliver on project goals and ensure complete client confidentiality and protection of Intellectual Property (IP).
Our medicinal chemistry services include:
- Hit Generation
- Hit-to-lead
- Lead optimisation
- Scale-up
- Scaffold-hopping
Proven track record in drug discovery
We have added value to a variety of medicinal chemistry projects for our partners, including many of the world's leading pharmaceutical and biotechnology companies.
Our medicinal chemists have contributed to drugs undergoing clinical development as well as marketed agrochemicals and pharmaceuticals.
Peakdale's medicinal chemists are listed as inventors on a variety of patents and the company
has a proven track record of helping customers establish IP and clearly adding value to the drug discovery process.
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Computational Chemistry Services and drug discovery
We place great emphasis on the close interaction between our medicinal chemists and our
Computational Chemistry Services to ensure timely, practical hypothesis testing to
meet project goals.
With extensive experience across therapeutic areas, we will apply appropriate tools from our computational capabilities to solve specific problems around a project, such as selectivity, potency physical properties and early ADME. Both 2D and 3D information from known active ligands is used to construct pharmacophores which guide our synthetic chemists in the design of highly focused arrays.
QSAR models are continually refined using new biological data to identify both favourable
and unfavourable regions of space, providing the construction of smaller more focussed arrays. This drug design process is used iteratively to obtain the final target profile.
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Drug Discovery
All of our medicinal chemistry is driven by the demands of modern drug design, working within property space to ensure rapid progression to the desired programme objectives.
At Peakdale we offer a range of in vitro ADMET predictive models, delivering accurate and
reproducible quality data, while maintaining a focus on efficient turnaround times to facilitate our customers' drug discovery programs. In addition to our core assays, we also offer our clients the flexibility of bespoke assay design.
Complementing our laboratory facilities, we have an in silico capability dedicated to virtual
high throughput screening for optimisation of ADMET properties aiding rational selection of compounds for in vitro experiments.
By combining our in silico and in vitro expertise, we can develop QSAR models to help predict
ADMET and utilise software capable of predicting common ADMET properties from 2D
structures. This information is invaluable in prioritising potential synthetic targets and can be trained using in vitro data generated either by a client or by our own in vitro ADME services.
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