- 9 Research laboratories with scales from mg to kg
- 2 Large contract research laboratories
- Scale-up laboratory reactors - 30Land 50L jacketed vessels
- Low temperature capabilities - up to 30 litres at -78°C
- Pressure vessels up to 7.8 litres
- Microwave reactors up to 1ml to 1l
- 5L & 10L test rigs for hazard evaluation
- 2 x 10L, 4 x 6L jacketed vessels
- Carius apparatus for reaction screening to assist with scale-up
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- Waters Mass Directed Preparative HPLC
- Parallel reaction blocks (Stem, Metz, Greenhouse, Carousel)
- Zinsser Lissy liquid handling
- Genevac HT12
- Parallel purification (filtration, Flashmaster)
- Growing reaction database
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- 5 Analytical HPLC (2 with MS), chiral chromatography
- UPLC-MS
- GC (FID)
- Karl Fischer
- 300MHz and 400MHz (Jeol) - NMR
- Open access 1D spectra for 1H, 13C, 19F, 11B and 31P - NMR
- Open access 2D spectra such as COSY, HETCOR, NOESY - NMR
- On request specialist experiments (1D nOe difference, other nuclei) - NMR
- Variable temperature - NMR
- Structural & purity confirmation/elucidation - NMR
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- 4 prep. HPLC with PDA and/or ELS
- Mass directed prep. HPLC
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- Thermo Fisher Triple Quad Mass spectrometer
- Serum /Plasma protein Binding
- Plasma stability (human + species on demand)
- Microsomal stability (human + species on demand)
- CYP450 inhibition
- Cytotoxicity
- CACO2 permeability (bidirectional)
- In silico & measured physical chemistry properties
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- Virtual screening
- Pharmacophore modelling and QSAR methods
- Ligand docking
- Protein homology modelling
- ADMET
- Array design
- Licensed software includes: Discovery Studio (Accelrys); Cresset's Molecular Field Software; Dragon
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- Extensive library of hard copy journals covering all important synthetic organic and medicinal chemistry literature
- Online access to Science Direct
- Literature searching capabilities include Reaxys and SciFinder
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